Collagen peptides are short chains of amino acids, derived from the enzymatic hydrolysis of native collagen protein, making them highly digestible and bioavailable upon oral ingestion. These fragments are not intended to function as a complete protein source but rather as specific signaling molecules and building blocks for the body’s connective tissues. Clinically, supplementation with collagen peptides is utilized to support the structural integrity and resilience of skin, joints, bone matrix, and the intestinal lining. They are a key component in nutritional strategies aimed at tissue health and longevity.
Origin
The term is derived from collagen, from the Greek kolla meaning “glue,” and peptide, meaning a short chain of amino acids, from the Greek peptos meaning “digested.” This combination accurately describes the functional, fragmented form of the body’s most abundant structural protein. The production process involves controlled hydrolysis to yield specific peptide sizes.
Mechanism
Upon absorption, the unique di- and tripeptides, such as proline-hydroxyproline, circulate in the bloodstream and are preferentially taken up by target tissues like the skin and cartilage. These specific peptides act as ligands, signaling local cells, such as fibroblasts and chondrocytes, to increase their endogenous synthesis of new collagen and other extracellular matrix components. They simultaneously provide the necessary amino acid precursors to support this accelerated synthesis and repair.
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