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Collagen Cross-Linking

Meaning

Collagen Cross-Linking is a biochemical process involving the formation of covalent bonds between adjacent collagen molecules, which are the primary structural proteins providing tensile strength to connective tissues, skin, and bone. While a controlled, enzymatic level of cross-linking is necessary for optimal tissue strength and stability, excessive or pathological cross-linking, often driven by the non-enzymatic reaction of glycation, stiffens tissues and significantly reduces elasticity. This excessive bonding is a well-recognized molecular hallmark of biological aging and contributes significantly to visible skin wrinkling and progressive vascular rigidity.