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Cognitive Substrate Purity

Meaning

Cognitive Substrate Purity is a conceptual term used to describe the optimal metabolic environment within the central nervous system, characterized by the efficient supply and utilization of high-quality energy sources and the minimal presence of neurotoxic metabolic byproducts. This state is essential for sustained high-level cognitive function, including memory consolidation, executive function, and neuroplasticity. Achieving this purity requires robust cerebral blood flow, tight glycemic control, and effective clearance of cellular waste, such as amyloid-beta and tau proteins. It reflects a state of metabolic health directly supporting neuronal signaling integrity.