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Cognitive Substrate Availability

Meaning

Cognitive Substrate Availability refers to the immediate and sustained access of the brain to the essential metabolic resources required for optimal neurological function, particularly energy substrates like glucose and ketone bodies, and critical micronutrients. The brain is a high-demand metabolic organ, and its performance in areas like focus, memory, and executive function is directly dependent on a stable supply of these biochemical building blocks. Impaired availability, often linked to insulin dysregulation or mitochondrial dysfunction, can manifest as ‘brain fog’ or cognitive decline. Optimizing this availability is a key target in neuro-metabolic health.