Question 1

What is the Meaning of Cognitive Runway Extension?

Accepted Answer

Cognitive runway extension is a metaphorical term used in longevity medicine to describe therapeutic and lifestyle interventions designed to prolong the period of peak cognitive function and delay the onset of age-related cognitive impairment. It signifies the proactive preservation of executive function, processing speed, and memory capacity well into advanced chronological age. The clinical objective is to increase the total number of years an individual maintains high-level intellectual performance.

Question 2

What is the Origin of Cognitive Runway Extension?

Accepted Answer

This phrase is derived from aviation terminology, where a "runway" represents the finite distance available for a safe landing or takeoff, and it has been adopted by the neuro-longevity field. It conceptually bridges the physiological process of neuroplasticity with the clinical goal of extending the cognitive healthspan. The term underscores the belief that cognitive decline is not an inevitable fate but a process that can be strategically managed.

Question 3

What is the Mechanism of Cognitive Runway Extension?

Accepted Answer

Achieving a cognitive runway extension involves multifaceted strategies that optimize cerebral metabolism, enhance synaptic connectivity, and support neurogenesis in key brain regions like the hippocampus. This often includes optimizing levels of neurosteroids and thyroid hormones, which are potent modulators of neuronal health and function. Regular cognitive training and adequate sleep hygiene are also integral components that support the biological mechanisms of neural network maintenance.

Cognitive Runway Extension

Meaning

Origin

Mechanism

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