A quantifiable metric reflecting the brain’s capacity to maintain executive function and cognitive throughput despite systemic stressors or age-related changes. This index measures the robustness of neural networks against factors like inflammation or fluctuating neuroendocrine support. High scores indicate preserved mental acuity under duress.
Origin
This construct bridges clinical neuropsychology with endocrinology, recognizing that hormonal balance, particularly sex steroids, directly underpins cognitive stability. It quantifies the brain’s ability to resist functional entropy.
Mechanism
Resilience is supported by adequate cerebral blood flow, efficient glucose metabolism, and low levels of neuroinflammation mediated by glial cell function. Optimal neurotrophic factor signaling, often supported by balanced cortisol profiles, allows neurons to rapidly adapt and recover from transient challenges to homeostasis.
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