The clinical objective of enhancing the physiological resilience and efficiency of memory retrieval and consolidation processes within the central nervous system, particularly in the context of hormonal fluctuations or age-related decline. This stabilization is directly linked to the optimal function of neurotrophic factors and key endocrine agents, like estrogens and androgens, within the hippocampus. A stabilized recall function is a core metric of neuroendocrine healthspan.
Origin
This term synthesizes concepts from cognitive neuroscience, which studies memory, and endocrinology, which details the profound influence of sex steroids and thyroid hormones on brain structure and function. Clinical translation focuses on the practical preservation of intellectual capacity throughout the lifespan.
Mechanism
Stabilization is achieved by optimizing the neuroendocrine environment, which includes ensuring adequate cerebral blood flow and managing oxidative stress that impairs synaptic plasticity. Key hormones act as neuroprotectants and modulators of long-term potentiation, the cellular basis of learning and memory. Maintaining appropriate levels of these circulating signals reinforces the neuronal pathways necessary for reliable memory recall.
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