Cognitive physiology is the study of the physical and chemical processes occurring within the brain that underpin mental functions such as memory, attention, executive function, and emotional regulation. It examines the intricate relationship between neural activity, cerebral blood flow, and the neuroendocrine environment. Optimal hormonal balance is foundational to maintaining the integrity and efficiency of these brain functions throughout the lifespan.
Origin
This term is a synthesis of “cognitive,” referring to the mental process of knowing, and “physiology,” the study of function, rooted in neuroscience and endocrinology. The understanding of the brain as a hormone-sensitive organ has driven the clinical focus on this area. It emerged from recognizing that cognitive health is inseparable from systemic physiological regulation, particularly the endocrine system.
Mechanism
Hormones, acting as neuromodulators or neurosteroids, directly influence neuronal excitability, synaptic plasticity, and the growth of new neurons. For example, estrogen and testosterone interact with specific receptors in the hippocampus and cortex to support memory consolidation and mood stability. Maintaining proper glucose metabolism and mitigating neuroinflammation are also crucial physiological mechanisms that sustain cognitive function.
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