Cognitive Performance Hormones encompass the endogenous signaling molecules that directly influence neurogenesis, synaptic function, and overall brain efficiency. Key examples include DHEA, testosterone, thyroid hormones, and cortisol, whose levels must remain within optimal physiological windows for peak mental output. Deficits in these areas correlate directly with measurable declines in executive function and processing speed. We assess these relationships clinically to guide interventions.
Origin
This nomenclature combines the functional domain of “Cognitive Performance” with the physiological agents, “Hormones,” that govern these functions. The term acknowledges that optimal cognition is not solely neurological but fundamentally dependent on endocrine signaling integrity. It reflects the understanding that brain health is inseparable from systemic hormonal regulation.
Mechanism
These hormones operate by binding to specific nuclear or membrane receptors within neuronal tissue, initiating transcription factors that regulate synaptic protein expression and neurotransmitter synthesis. For instance, testosterone influences dendritic arborization, while optimal thyroid hormone action is necessary for overall cellular metabolic rate in the brain. Proper signaling ensures rapid signal transduction across neural networks.
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