Cognitive Longevity denotes the successful preservation of mental acuity, including executive function, memory recall, and processing speed, extending deep into advanced age. This concept moves beyond mere absence of disease to focus on maximizing enduring cognitive reserve and plasticity. It is a critical marker of overall systemic health.
Origin
This modern concept merges ‘cognition,’ relating to mental processes, with ‘longevity,’ emphasizing sustained function over a long lifespan. It frames mental health as a quantifiable, achievable long-term goal.
Mechanism
Sustaining cognitive longevity requires robust cerebral microcirculation, adequate neurotrophic support, and minimized exposure to chronic neuroinflammation. Optimal neurosteroid balance, influenced by gonadal and adrenal hormones, is essential for synaptic maintenance and mitigating age-related neuronal degradation.
Long-term cognitive outcomes from lifestyle and endocrine support involve neuro-endocrine-metabolic recalibration, enhancing brain resilience and function.
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