Cognitive Longevity Science is the interdisciplinary field dedicated to understanding and intervening in the biological processes that maintain high-level cognitive function across the lifespan. Its objective is to mitigate age-related neurodegeneration and maintain neuroplasticity well into advanced years. This area strongly intersects with endocrinology due to the role of sex hormones and thyroid function in brain health.
Origin
The concept combines “Cognition” with “Longevity,” reflecting a modern scientific focus on extending the period of high-quality mental function rather than merely extending lifespan. It draws heavily from gerontology and neurobiology.
Mechanism
Interventions often target mechanisms such as reducing neuroinflammation, optimizing cerebral insulin signaling, and supporting trophic factor release like BDNF. Hormonal balance is crucial, as deficient steroid hormones or dysregulated thyroid axes accelerate cognitive decline by impairing neuronal maintenance cycles.
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