What is the Origin of Cognitive Load Tolerance?

This term is borrowed from cognitive psychology and applied to neuroendocrinology to link mental processing limits with underlying biochemical states. It quantifies the brain's ability to function optimally when energy substrates and stress hormones are fluctuating.

What is the Mechanism of Cognitive Load Tolerance?

Tolerance is directly influenced by the availability of glucose and ketone bodies for neuronal fuel, alongside the acute regulation of circulating cortisol and thyroid hormones impacting synaptic plasticity. Efficient signaling within prefrontal cortical networks, supported by adequate neurotrophic factors, dictates the upper limit of manageable complexity before system failure occurs.

Cognitive Load Tolerance

Meaning

The quantifiable capacity of the central nervous system to process complex information and maintain executive function while under concurrent physiological stress, often modulated by the hormonal environment. It represents the brain’s reserve before cognitive resources become depleted, leading to errors or mental fatigue. This capacity is deeply tied to neuroendocrine stability.