Cognitive Lifespan is the duration of an individual’s life during which they maintain high-level, functional cognitive abilities, including memory, reasoning, and processing speed, free from significant age-related neurocognitive impairment. This concept is a key metric in longevity research, focusing on the quality and robustness of mental function across the entire healthspan. It is distinct from chronological lifespan, emphasizing the vitality of the central nervous system.
Origin
This term originates from the intersection of gerontology, public health, and cognitive epidemiology, reflecting a societal and clinical shift from merely extending life to extending healthy and functional life. The measurement of cognitive lifespan is directly tied to the understanding of neurodegenerative processes and the search for effective preventative strategies. It is an evolution of the broader concept of healthspan, specifically applied to the brain.
Mechanism
Maintaining a robust cognitive lifespan relies on preserving neuronal integrity and synaptic plasticity throughout the aging process. Hormonal balance, particularly optimal thyroid and sex hormone levels, is crucial for supporting neuronal metabolism and structure. Minimizing chronic neuroinflammation and mitigating the accumulation of pathological protein aggregates, such as amyloid plaques, are key biological strategies for preserving long-term cognitive function and resilience.
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