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Cognitive Impact of HRT

Meaning

The Cognitive Impact of HRT describes the measurable effects, both beneficial and potentially adverse, that Hormone Replacement Therapy has on brain function, encompassing domains such as memory, executive function, processing speed, and mood regulation. Steroid hormones, including estrogens and testosterone, act as neurosteroids, exerting pleiotropic effects on neuronal structure, synaptic plasticity, and neurotransmitter systems throughout the central nervous system. Clinical research seeks to delineate the timing, dosage, and specific hormonal agents that optimize cognitive outcomes, especially during the perimenopausal and postmenopausal transitions.