The physiological state characterized by the stable, continuous availability of metabolic resources, primarily glucose and oxygen, to the central nervous system to support prolonged periods of mental focus, executive function, and optimal cognitive performance. Within the context of hormonal health, this refers to optimizing endocrine signaling pathways that regulate neuronal energy metabolism. It is a critical aspect of overall longevity and well-being.
Origin
This concept stems from the convergence of neuroscience, endocrinology, and metabolic physiology, recognizing that sustained mental output is not merely a psychological effort but a reflection of efficient bioenergetic regulation. The term emphasizes a long-term, homeostatic balance rather than transient energy spikes.
Mechanism
The sustainment mechanism relies heavily on the neuroendocrine axis, where hormones like cortisol, thyroid hormones, and insulin regulate systemic glucose homeostasis and mitochondrial function within brain cells. Optimized hormonal balance ensures consistent neurotransmitter synthesis and efficient ATP production, preventing the cognitive decline associated with metabolic dysregulation or hormonal deficiency.
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