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Cognitive Energy Substrate

Meaning

The Cognitive Energy Substrate refers to the primary molecular compounds that the brain efficiently utilizes to fuel its intense and continuous metabolic demands, which are essential for sustained neurological function. Glucose is typically the brain’s main substrate, but under specific metabolic conditions, ketone bodies and certain medium-chain fatty acids become critical and highly efficient alternative fuel sources. Optimizing the reliable delivery and efficient utilization of these substrates is crucial for maintaining mental clarity, executive function, and overall cognitive performance. Dysregulation or chronic deficiency in substrate utilization can manifest clinically as cognitive fatigue or impaired focus.