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Cognitive Decline Markers

Meaning

Cognitive decline markers are measurable biochemical, physiological, or structural indicators that correlate with or predict a progressive deterioration in cognitive domains such as memory, executive function, and processing speed. These biomarkers are critical clinical tools used for early detection, prognosis, and monitoring of therapeutic efficacy in conditions ranging from mild cognitive impairment to advanced neurodegenerative diseases. Specific lipid profiles and hormonal metabolites often serve as reliable molecular indicators of this decline.