This term denotes the sustained preservation of mental acuity, focus, and executive function over time, preventing the subtle decline in cognitive processing speed and memory recall often associated with aging. Achieving this maintenance involves supporting optimal neuronal health and neurotransmitter balance within the central nervous system. It reflects a high level of neurophysiological efficiency.
Origin
This concept is rooted in the intersection of neuroendocrinology and geriatric medicine, focusing on the preservation of cognitive reserve. The “maintenance” aspect emphasizes a proactive, long-term strategy, often involving hormonal and metabolic support.
Mechanism
Hormones like estradiol and testosterone, alongside neurotrophic factors such as Brain-Derived Neurotrophic Factor (BDNF), play a crucial role in promoting synaptic plasticity and neurogenesis. These factors modulate the production and reception of key neurotransmitters, ensuring efficient signal transmission and sustained communication between neuronal networks essential for complex thought processes.
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