The targeted enhancement of the structural and functional integrity of the brain’s cognitive systems, focusing on the efficiency of information processing, memory encoding, and executive control. Optimization seeks to improve the underlying neural networks that support complex thought processes, making them more resilient to stress and age-related decline. This approach directly addresses the physical and chemical environment necessary for superior mental performance.
Origin
This term merges cognitive science, which studies the “architecture” of thought processes, with the engineering concept of “optimization,” which means making something as effective as possible. In the clinical context, it signifies a systematic intervention to improve the hardware and software of the brain. The concept is closely linked to neuroplasticity and brain reserve theory.
Mechanism
Optimization relies heavily on promoting neurogenesis and synaptogenesis, the formation of new neurons and synapses, often mediated by growth factors like BDNF. Key hormonal pathways, particularly those involving thyroid hormones and sex steroids, are modulated to support myelin integrity and efficient neural communication. This comprehensive mechanism improves neuronal energy metabolism and reduces neuroinflammation, which are common inhibitors of cognitive function.
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