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Coagulation Risk

Meaning

Coagulation risk, in the context of hormonal health, refers to the physiological probability of developing a thromboembolic event, such as deep vein thrombosis (DVT) or pulmonary embolism (PE), often influenced by endogenous or exogenous hormonal factors. Certain hormones, particularly estrogens, can modulate the hepatic synthesis of coagulation factors and anti-coagulation proteins, thereby shifting the body’s hemostatic balance toward a prothrombotic state. Clinical assessment of this risk is paramount when initiating hormone replacement therapy (HRT) or oral contraceptives. A thorough patient history, including genetic predispositions and lifestyle factors, is essential for mitigation.