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Coagulation Cascade

Meaning

The coagulation cascade is a complex, sequential series of enzymatic reactions involving various plasma proteins, known as clotting factors, that ultimately leads to the formation of a stable fibrin clot. This vital hemostatic process is essential for stopping blood loss following vascular injury, functioning as the body’s primary mechanism for achieving secondary hemostasis. Its precise regulation is critical, as deficiencies can cause bleeding disorders, while overactivity can lead to pathological thrombosis.