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Co-Activator Sequestration

Meaning

Co-activator sequestration is a sophisticated molecular mechanism involving the competitive binding and subsequent retention of transcriptional co-activator proteins by specific nuclear receptors or other highly active transcription factors. This cellular process effectively reduces the overall availability of these essential co-activators for other signaling pathways that rely on them to initiate gene expression. The functional outcome is a targeted dampening or redirection of gene transcription in specific hormonal or cellular contexts. This mechanism is central to understanding the selective action of certain endocrine-modulating therapeutic agents.