What is the Origin of CNS Depression?

The term is descriptive, combining the anatomical system, the Central Nervous System, with the physiological state of 'depression,' which in this context means a functional decrease in activity, not the psychiatric condition. It is a fundamental concept in toxicology and pharmacology used to classify the effects of many psychoactive and sedative agents.

What is the Mechanism of CNS Depression?

The depressive state is most commonly mediated by pharmacological agents that enhance the inhibitory effects of the primary inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), or block the action of excitatory neurotransmitters like glutamate. This potentiation of inhibitory signaling leads to the hyperpolarization of neurons, effectively reducing the frequency of action potentials and causing a systemic decrease in central neuronal firing rates.

CNS Depression ∞ Area

CNS Depression

Meaning

CNS Depression, an abbreviation for Central Nervous System Depression, is a state of reduced neurological activity across the brain and spinal cord, clinically characterized by a spectrum of symptoms ranging from mild sedation and impaired coordination to life-threatening respiratory depression and coma. This condition signifies a generalized slowing of neuronal function.