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Cmax Trough Fluctuation

Meaning

Cmax Trough Fluctuation is a pharmacokinetic measure that quantifies the difference between the maximum (Cmax) and minimum (Trough) plasma concentrations of a drug or hormone during a dosing interval. This metric is a direct indicator of the variability and pulsatility of systemic exposure following a specific administration regimen. Minimizing this fluctuation is often a primary goal in hormonal replacement therapy to achieve Endocrine Signaling Stability and avoid undesirable peak-and-trough side effects. High fluctuations can lead to periods of supra-therapeutic effects followed by sub-therapeutic effects.