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Clinical Significance

Meaning

Clinical Significance denotes the practical relevance and impact of a specific laboratory finding, such as an abnormal hormone level, on patient diagnosis, prognosis, or treatment strategy within the sphere of endocrinology. A finding possesses clinical significance when it necessitates a change in patient management or accurately predicts a meaningful physiological outcome, distinguishing it from mere statistical variation. We assess significance by determining if the deviation from the established reference range translates to tangible patient morbidity or benefit from intervention. It is the bridge between laboratory data and actionable patient care.