Clinically guided, evidence-based therapeutic strategies specifically designed to extend healthspan and enhance physiological resilience against age-related decline. These interventions move beyond disease treatment to proactively optimize biological systems, including endocrine and metabolic function. They encompass pharmacological agents, targeted nutraceuticals, and specific lifestyle modifications integrated under medical supervision.
Origin
This discipline finds its roots in gerontology and preventive medicine, but the modern ‘clinical longevity’ term crystallized with the scientific understanding of the molecular hallmarks of aging. The focus shifted from merely treating geriatric illness to intervening in fundamental biological aging pathways. It represents a progressive evolution of anti-aging medicine toward rigorous, translational science.
Mechanism
The interventions function by targeting key aging mechanisms, such as cellular senescence, mitochondrial dysfunction, and chronic low-grade inflammation, often closely regulated by the endocrine system. For instance, hormone optimization protocols or metabolic regulators are used to restore youthful signaling patterns. These strategies aim to modulate specific biological pathways to improve overall cellular maintenance and repair capacity.
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