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Clinical Hypogonadism

Meaning

Clinical hypogonadism is a well-defined endocrinological condition characterized by a deficiency in the production of sex hormones, such as testosterone or estrogen, by the gonads—testes in males and ovaries in females. This hormonal deficit is often accompanied by impaired spermatogenesis or oogenesis, impacting reproductive capacity and systemic health. Diagnosis relies on the correlation of specific clinical signs and symptoms with consistently low measured serum hormone levels. Recognizing this condition is vital because it significantly affects quality of life, bone mineral density, sexual function, and metabolic health across the lifespan.