What is the Origin of CKD-MBD?

This unified nomenclature was established by international consensus groups to group the skeletal and extraskeletal manifestations resulting from the progressive loss of renal endocrine function. It moves beyond simple bone disease to encompass systemic mineral dysregulation.

What is the Mechanism of CKD-MBD?

As glomerular filtration rate declines, the kidney's ability to excrete phosphate and activate calcitriol diminishes, leading to hyperphosphatemia and relative Vitamin D deficiency. This imbalance alters parathyroid hormone (PTH) secretion, initiating cycles of high or low bone turnover, ultimately resulting in the pathological bone fragility characteristic of the syndrome.

CKD-MBD ∞ Area

CKD-MBD

Meaning

CKD-MBD stands for Chronic Kidney Disease-Mineral and Bone Disorder, a complex systemic disorder arising from chronic renal impairment that profoundly disrupts calcium, phosphate, and Vitamin D metabolism, directly affecting skeletal health and vascular calcification risk. This disorder highlights the critical endocrine role of the failing kidney.