Question 1

What is the Meaning of CJC1295?

Accepted Answer

CJC1295 is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH), classified as a Growth Hormone Secretagogue (GHS). This peptide is engineered to have a significantly prolonged half-life due to its ability to bind covalently to endogenous albumin in the plasma. By mimicking the action of natural GHRH, it stimulates the pituitary gland to secrete Growth Hormone (GH) in a pulsatile and physiological manner. Clinical interest centers on its potential for improving body composition, enhancing recovery, and supporting overall metabolic function.

Question 2

What is the Origin of CJC1295?

Accepted Answer

The development of CJC1295 stems from the initial discovery and characterization of the natural GHRH peptide, which controls the release of growth hormone from the anterior pituitary gland. Scientists chemically modified the GHRH sequence, adding a Drug Affinity Complex (DAC) to the peptide structure to achieve bioconjugation with albumin. This structural modification was intentionally designed to extend the therapeutic window and reduce the frequency of administration compared to the native hormone.

Question 3

What is the Mechanism of CJC1295?

Accepted Answer

The peptide functions by binding to the GHRH receptors on somatotroph cells in the anterior pituitary gland. This binding action initiates the intracellular signaling cascade, ultimately leading to the synthesis and pulsatile release of stored Growth Hormone. The DAC modification allows the molecule to circulate for an extended period, continuously presenting the stimulus to the pituitary and thus maintaining elevated, yet physiological, levels of GH secretion. This sustained stimulation promotes downstream effects mediated by Insulin-like Growth Factor 1 (IGF-1).

CJC1295

Meaning

Origin

Mechanism

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