The CJC-1295 Protocol refers to the prescribed regimen for administering the synthetic peptide CJC-1295, a long-acting Growth Hormone-Releasing Hormone (GHRH) analog. This specific protocol is designed to achieve a sustained, pulsatile release of endogenous growth hormone from the pituitary gland, avoiding the pharmacological peaks associated with exogenous growth hormone administration. The primary clinical objective is to optimize the physiological benefits of elevated growth hormone and Insulin-like Growth Factor 1 (IGF-1) levels.
Origin
The term is a clinical and research designation derived from the pharmaceutical development of the CJC-1295 molecule, which was engineered to have a long half-life. The protocol aspect relates to the structured, often cyclical, administration schedule required to leverage the drug’s sustained release mechanism. This approach aims to mimic the body’s natural pulsatile hormone secretion pattern.
Mechanism
CJC-1295 achieves its extended action through Drug Affinity Complex (DAC) technology, which allows the peptide to covalently bind to circulating serum albumin. This binding protects the peptide from rapid enzymatic degradation, significantly extending its half-life to several days. The prolonged presence of the GHRH analog in the circulation continuously stimulates somatotroph cells in the anterior pituitary, leading to an amplified and steady secretion of growth hormone. This mechanism sustains elevated IGF-1 levels, mediating many of the peptide’s systemic effects.
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