What is the Origin of CJC-1295 Ipamorelin?

These peptides are products of modern pharmaceutical and endocrinological research aimed at developing secretagogues that safely enhance endogenous GH secretion. CJC-1295 was developed to be a long-acting version of GHRH, and Ipamorelin was synthesized as a highly selective GHRP with minimal impact on cortisol or prolactin release. Their combined use reflects a clinical strategy to mimic the body's natural GH pulse.

What is the Mechanism of CJC-1295 Ipamorelin?

CJC-1295 binds to the GHRH receptors on the pituitary gland, stimulating the synthesis and release of GH. Simultaneously, Ipamorelin selectively binds to the ghrelin receptor, also known as the Growth Hormone Secretagogue Receptor (GHSR), triggering a robust GH release from the pituitary. This dual action amplifies the release of GH, which subsequently travels to the liver to stimulate the production of Insulin-like Growth Factor 1 (IGF-1), mediating many of the anabolic and regenerative effects.

CJC-1295 Ipamorelin

Meaning

CJC-1295 Ipamorelin is a specific therapeutic combination of two synthetic peptides used clinically to stimulate the body’s natural production and pulsatile release of Growth Hormone (GH). CJC-1295 is a Growth Hormone Releasing Hormone (GHRH) analog that extends its half-life, while Ipamorelin is a Growth Hormone Releasing Peptide (GHRP) that mimics ghrelin’s action. The synergistic effect of these two peptides results in a more sustained and physiological release of GH.

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