What is the Origin of CJC-1295 Growth Hormone?

This compound originated from pharmaceutical research focused on overcoming the short half-life characteristic of native GHRH peptides. The modification, often involving Drug Affinity Complex (DAC) technology, was engineered to enhance its duration of action in the circulation. Its naming reflects its developmental lineage within peptide chemistry.

What is the Mechanism of CJC-1295 Growth Hormone?

The primary mechanism involves binding to GHRH receptors on anterior pituitary somatotrophs, mimicking the action of GHRH to stimulate the pulsatile release of GH into the systemic circulation. The DAC component, often involving albumin binding, extends the peptide's presence, leading to sustained, rather than acute, GH elevation. This sustained signaling encourages a more physiological pattern of GH release compared to exogenous GH administration.

CJC-1295 Growth Hormone ∞ Area

CJC-1295 Growth Hormone

Meaning

CJC-1295 is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH) designed for prolonged action, specifically used to stimulate the pituitary gland to increase endogenous Growth Hormone (GH) secretion. Clinically, it is assessed for its potential to normalize GH levels in states of deficiency, thereby supporting anabolic processes and body composition goals. It represents a pharmacological approach to augmenting the somatotropic axis.

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HRTioSeptember 30, 2025

CJC-1295 Growth Hormone

Meaning

Origin

Mechanism

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