What is the Meaning of CJC-1295 and Ipamorelin?

CJC-1295 and Ipamorelin are synthetic peptide compounds often used in combination clinically as Growth Hormone-Releasing Hormone analogues and Growth Hormone Secretagogues, respectively. CJC-1295 is a long-acting peptide that mimics GHRH, while Ipamorelin is a selective GHS that acts on the ghrelin receptor. Their combined use aims to stimulate the pulsatile and physiological release of endogenous Growth Hormone from the pituitary gland.

What is the Origin of CJC-1295 and Ipamorelin?

Both peptides were developed through pharmaceutical research aimed at creating agents capable of modulating the somatotropic axis for therapeutic purposes, such as addressing Growth Hormone Deficiency. CJC-1295 was engineered with a Drug Affinity Complex to extend its half-life, while Ipamorelin was designed for high selectivity to minimize side effects often associated with other GHS compounds. Their clinical pairing is a strategy for sustained, synergistic GH elevation.

What is the Mechanism of CJC-1295 and Ipamorelin?

CJC-1295 binds to the GHRH receptors on the somatotroph cells of the anterior pituitary, promoting both the synthesis and secretion of GH. Concurrently, Ipamorelin acts on the ghrelin receptor (GHSR-1a) in the pituitary and hypothalamus, further enhancing GH release and suppressing somatostatin, the inhibitory hormone. This dual-action mechanism works synergistically to amplify the natural pulsatile release of GH, leading to downstream increases in Insulin-like Growth Factor 1.

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