CJC-1295 Analog Function refers to the specific biological activity of a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH), designed to sustain and amplify the body’s natural pulsatile release of Growth Hormone (GH). This analog is chemically modified with a Drug Affinity Complex (DAC) to significantly extend its half-life, allowing for less frequent dosing while maintaining a stable, elevated level of GHRH activity. The functional outcome is a more consistent physiological stimulation of the pituitary gland, leading to enhanced endogenous GH and Insulin-like Growth Factor 1 (IGF-1) secretion. Clinically, this function supports anabolic processes, lipolysis, and overall metabolic health.
Origin
The peptide was developed in the early 2000s by ConjuChem Biotechnologies (CJC), hence the name, as part of efforts to create long-acting therapeutics for GH deficiency. The ‘analog function’ highlights its structural similarity to the native GHRH peptide but with superior pharmacokinetic properties due to the DAC modification. This engineering breakthrough shifted the clinical approach from short-acting daily injections to less frequent, sustained stimulation.
Mechanism
The DAC component of the analog binds reversibly to endogenous serum albumin, effectively protecting the peptide from rapid enzymatic degradation and clearance. This prolonged circulation time allows the analog to continuously engage GHRH receptors on somatotroph cells in the anterior pituitary. The sustained receptor binding then triggers a prolonged, physiological increase in GH secretion, which subsequently stimulates the liver to produce IGF-1, driving downstream effects like tissue repair and improved body composition.
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