Question 1

What is the Meaning of Citrulline Malate?

Accepted Answer

Citrulline Malate is a compound combining the non-essential amino acid L-citrulline with malate, a dicarboxylic acid, often used in clinical and sports nutrition for its ergogenic and vascular benefits. L-citrulline serves as a potent precursor to L-arginine, the substrate for nitric oxide synthesis, while malate plays a key role in the tricarboxylic acid cycle. This combination is valued for enhancing circulatory function and mitigating fatigue, which supports the physiological foundation for hormonal optimization and performance.

Question 2

What is the Origin of Citrulline Malate?

Accepted Answer

L-citrulline was first isolated from watermelon, Citrullus vulgaris, which gives the compound its name. Its clinical utility gained recognition through research into the urea cycle and subsequently the nitric oxide pathway, demonstrating its superior capacity to elevate plasma arginine levels compared to direct arginine supplementation. The addition of malate is a formulation refinement to enhance metabolic energy production, bridging the compound's benefit across vascular and muscular physiology.

Question 3

What is the Mechanism of Citrulline Malate?

Accepted Answer

Upon ingestion, L-citrulline is efficiently absorbed and converted into L-arginine in the kidneys, bypassing the extensive first-pass metabolism that limits oral arginine. L-arginine is then used by endothelial cells to produce nitric oxide (NO), a powerful vasodilator that improves blood flow and nutrient delivery to peripheral tissues, including muscle and reproductive organs. The malate component contributes to aerobic energy production, potentially reducing the perception of effort and accelerating the clearance of metabolic waste products like ammonia and lactate.

Citrulline Malate

Meaning

Origin

Mechanism

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