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Circumventricular Organs

Meaning

These are highly specialized neurovascular structures situated along the midline ventricles of the brain, characterized by a deliberate absence of a complete blood-brain barrier. This unique anatomical configuration permits direct, bidirectional communication between the central nervous system and the systemic circulation, facilitating the crucial exchange of hormones, peptides, and various regulatory factors. They serve as critical sensing and signaling hubs for maintaining fluid homeostasis and neuroendocrine regulation.