What is the Origin of Circulating MicroRNAs?

The discovery of microRNAs began in the early 1990s in C. elegans, with their widespread presence in human cells and circulation being recognized later, linking genetics to complex disease mechanisms. The term 'circulating' emphasizes their presence outside of cells, providing an accessible window into internal biological processes.

What is the Mechanism of Circulating MicroRNAs?

Secreted by cells, these microRNAs travel through the circulation to target cells where they bind to complementary sequences on target messenger RNA molecules. This binding typically results in the repression of protein synthesis or the degradation of the mRNA transcript. Consequently, circulating microRNA profiles can serve as highly sensitive indicators of cellular stress, hormonal imbalances, or early disease states, reflecting changes in tissue-specific gene regulation.

Circulating MicroRNAs ∞ Area

Circulating MicroRNAs

Meaning

Circulating microRNAs, or miRNAs, are small, non-coding RNA molecules typically 19 to 25 nucleotides in length that are stably present in the bloodstream, often encapsulated within extracellular vesicles like exosomes. These molecules are critical post-transcriptional regulators of gene expression, influencing the translation of messenger RNA (mRNA) into proteins. Their concentration and specific profiles reflect the physiological and pathological status of distant cells and tissues, offering a novel class of biomarkers.

Male subject with damp hair and towel, embodying post-recovery from a hormone optimization protocol. This reflects the patient journey toward metabolic health, emphasizing cellular regeneration, clinical wellness, endocrine balance, and physiological well-being, often supported by peptide therapy.

Are There Specific Biomarkers That Predict Metabolic Response to Lifestyle Interventions after Cancer Treatment?

Specific biomarkers, including inflammatory markers, sex hormones, and gut microbiome profiles, predict metabolic response to lifestyle changes post-cancer treatment.

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∞ Inflammatory Markers

HRTioAugust 30, 2025

Circulating MicroRNAs

Meaning

Origin

Mechanism

Are There Specific Biomarkers That Predict Metabolic Response to Lifestyle Interventions after Cancer Treatment?

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