What is the Origin of Circulating Hormones?

The concept is central to the discipline of endocrinology, which is fundamentally defined by the study of hormones and their actions via the circulatory system. The term 'circulating' emphasizes the long-distance, systemic nature of endocrine signaling, distinguishing it from paracrine or autocrine signaling which act locally. Measurement of these blood-borne molecules is the foundation of diagnostic hormonal panels.

What is the Mechanism of Circulating Hormones?

Upon secretion into the circulation, steroid hormones typically bind to carrier proteins, such as globulins and albumin, while peptide hormones often circulate freely. The bound fraction serves as a reservoir, while the unbound, or free, fraction is biologically active and able to diffuse across capillary walls to interact with cellular receptors. This transport mechanism ensures a stable, systemic distribution and regulated bioavailability of the hormones to all responsive tissues throughout the body.

Circulating Hormones

Meaning

Endocrine signaling molecules, synthesized and secreted by ductless glands, that travel through the bloodstream to exert their effects on distant target cells possessing specific receptors. These hormones include peptides, amines, and steroids, and they function as chemical messengers to regulate virtually all physiological processes, from metabolism and growth to mood and reproduction. Their concentration in the peripheral blood is a key metric used in clinical endocrinology to assess glandular function and systemic hormonal status.

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Circulating Hormones

Meaning

Origin

Mechanism

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How Does Urine Hormone Analysis Compare to Blood Testing for Hormonal Balance?

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