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Circulating Hormone Variance

Meaning

Circulating hormone variance describes the natural, often predictable, fluctuations in the concentration of hormones within the bloodstream over a given time period, such as a day (circadian rhythm) or a month (infradian rhythm). This variance is a critical physiological characteristic, as hormones are rarely static, and their pulsatile release and rhythmic changes are essential for proper biological signaling. Clinical interpretation of hormone panels must account for this inherent variance to avoid misdiagnosis and ensure therapeutic accuracy. It highlights the importance of timed blood draws in endocrinology.