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Circulating Hormone Half-Life

Meaning

Circulating Hormone Half-Life is the precise endocrinological measure of the time required for the concentration of a specific hormone in the peripheral blood circulation to decrease by exactly half its peak value. This pharmacokinetic parameter is a critical determinant of the hormone’s effective biological duration of action and thus the necessary frequency of clinical dosing. Hormones with inherently longer half-lives provide more stable, sustained receptor stimulation, while those with shorter half-lives necessitate pulsatile or frequent administration protocols.