What is the Origin of Circadian Rhythm Dysregulation?

The term combines the concept of the 'circadian rhythm'—from the Latin circa diem, meaning 'around a day'—with 'dysregulation,' denoting a disturbance in its normal, precisely timed function. This area is central to chronobiology and sleep medicine.

What is the Mechanism of Circadian Rhythm Dysregulation?

The suprachiasmatic nucleus (SCN) serves as the master pacemaker, coordinating peripheral clocks in organs like the liver and pancreas via neural and hormonal signals. Dysregulation occurs when external cues, like artificial light exposure at night or irregular feeding times, interfere with the SCN's synchronization, leading to inappropriate timing of cortisol, melatonin, and insulin secretion, thereby compromising metabolic and endocrine health.

Circadian Rhythm Dysregulation ∞ Area

Circadian Rhythm Dysregulation

Meaning

Circadian Rhythm Dysregulation describes a state where the body’s internal 24-hour biological clock is misaligned with the external light-dark cycle or the required behavioral schedule. This misalignment disrupts the predictable, time-dependent release of numerous hormones, neurotransmitters, and metabolic processes. Clinically, this is associated with impaired sleep, metabolic syndrome, and increased risk for various chronic diseases.