Skip to main content

Circadian Rhythm Disruption

Meaning

A state of misalignment where the body’s internal 24-hour biological clock, regulated by the suprachiasmatic nucleus, deviates significantly from the external light-dark cycle and behavioral routines. This desynchronization impacts the pulsatile release of key hormones, including cortisol and melatonin, which are essential for homeostasis. Chronic disruption is clinically associated with metabolic dysfunction and compromised immune surveillance.