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Circadian Clock Genes

Meaning

Circadian Clock Genes are a set of highly conserved genes found in nearly all cells that generate and maintain the endogenous, approximately 24-hour rhythm of physiological processes, collectively forming the molecular clockwork. These core genes, including CLOCK, BMAL1, PER, and CRY, encode proteins that interact in an intricate transcriptional-translational feedback loop. The rhythmic expression of these genes dictates the timing of countless downstream biological functions, ranging from hormone release to cellular metabolism. Their proper function is essential for a robust and healthy circadian system, influencing overall health and disease susceptibility.