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Ciliary Neurotrophic Factor

Meaning

Ciliary Neurotrophic Factor (CNTF) is a pleiotropic protein belonging to the cytokine family, primarily recognized for its role in promoting the survival and differentiation of various cell types, particularly motor neurons and oligodendrocytes in the nervous system. Beyond its profound neuroprotective effects, CNTF also functions as a metabolic regulator, often exerting anorexigenic effects that influence energy balance and body weight via central hypothalamic pathways. In clinical contexts, its potent anti-inflammatory and neurotrophic properties make it a subject of intense interest for treating neurodegenerative and specific metabolic disorders.