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Chronotherapy

Meaning

Chronotherapy is a clinical strategy that involves timing the administration of medications or therapeutic interventions to coincide with specific, predictable fluctuations in the body’s circadian and ultradian rhythms to optimize efficacy and minimize adverse effects. This precise approach acknowledges that the pharmacokinetics and pharmacodynamics of drugs, as well as the activity of certain diseases, are profoundly influenced by the body’s internal biological clock. In endocrinology, this often translates to hormone replacement protocols that meticulously mimic the natural diurnal secretion patterns.