Question 1

What is the Meaning of Chronology of Hormonal Effect?

Accepted Answer

The Chronology of Hormonal Effect refers to the precise time-dependent sequence and duration of biological responses elicited by a hormone or a hormone-mimicking agent following administration. This concept details the initial rapid, non-genomic effects, followed by the slower, sustained genomic effects involving gene expression and protein synthesis. Understanding this temporal profile is crucial for optimizing clinical dosing and timing to align with the body's natural circadian rhythms and desired therapeutic windows. It dictates how frequently a compound must be administered for continuous effect.

Question 2

What is the Origin of Chronology of Hormonal Effect?

Accepted Answer

This phrase originates from classical endocrinology and chronopharmacology, fields that study the timing of drug action relative to biological rhythms. 'Chronology' emphasizes the sequential nature of the physiological changes induced by the signaling molecule over time. It recognizes that hormonal action is not instantaneous but unfolds over minutes, hours, or days, which profoundly impacts clinical strategy and patient compliance. The body's intrinsic timing mechanisms must be respected.

Question 3

What is the Mechanism of Chronology of Hormonal Effect?

Accepted Answer

The mechanism begins with the hormone binding to its specific cell surface or intracellular receptor, initiating a rapid signal transduction cascade. This immediate response leads to short-term changes in enzyme activity or ion channel function. Subsequently, the hormone-receptor complex often translocates to the nucleus to modulate gene transcription, resulting in the slower synthesis of new proteins that mediate the long-term, sustained biological effects. The difference in these two phases defines the full chronological profile.

Chronology of Hormonal Effect

Meaning

Origin

Mechanism

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