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Chronological Passage Effect

Meaning

The Chronological Passage Effect describes the inevitable and cumulative physiological changes that occur within an organism purely as a function of the elapsed time since birth, independent of specific disease states or environmental factors. This intrinsic biological clock contributes to the gradual decline in systemic functional reserve and adaptive capacity observed across the lifespan. Clinically, it represents the background rate of senescence that health optimization strategies aim to slow or mitigate. Understanding this effect provides a realistic context for setting health and longevity goals.