Chronological Degradation Override is a theoretical and clinical objective focused on implementing interventions that actively slow, halt, or potentially reverse the age-associated functional decline observed in biological systems, effectively decoupling chronological age from biological age. This strategy targets the primary hallmarks of aging, such as cellular senescence, telomere attrition, and epigenetic dysregulation. The term implies a deliberate, science-driven effort to restore youthful physiological function and extend healthspan. It is a core tenet of advanced longevity medicine.
Origin
This term stems from the convergence of gerontology, molecular biology, and regenerative medicine, particularly the identification of conserved aging pathways like mTOR and sirtuins. The concept of “override” is used to convey a purposeful intervention that supersedes the natural trajectory of senescence and degradation. This ambitious goal is driven by research into epigenetic clocks and their modifiability.
Mechanism
The mechanism often involves activating endogenous repair and survival pathways, notably through the modulation of nutrient-sensing pathways like AMPK and sirtuins, which enhance cellular resilience and promote mitochondrial biogenesis. Specific hormonal optimization, such as maintaining youthful levels of growth hormone and sex steroids, also plays a critical role in preserving tissue integrity and function. By targeting the underlying molecular drivers of aging, the goal is to improve cellular clearance mechanisms and reduce the accumulation of damaged macromolecules.
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