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Chronological Biomarker Drift

Meaning

Chronological Biomarker Drift describes the measurable, progressive deviation of key physiological and molecular indicators from their youthful, optimal set points as an organism ages. This drift is a direct and quantifiable consequence of chronological time and is distinct from acute pathological disease states, representing the normative, age-related decline in systemic homeostatic efficiency. Examples include the gradual rise in chronic inflammatory markers, the steady decline in anabolic hormone levels, and the progressive shortening of telomere length. Understanding and quantifying this drift is absolutely central to proactive longevity medicine.