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Chronological Age Dissociation

Meaning

Chronological Age Dissociation describes the clinical and biological goal of achieving a measurable difference between an individual’s chronological age (years lived) and their biological age (functional state of tissues and organ systems). It is based on the premise that the rate of aging is modifiable and can be quantified using epigenetic clocks, telomere length, and functional biomarkers of physiological reserve. Dissociation implies a therapeutic intervention has successfully slowed, halted, or partially reversed the biological aging trajectory. The clinical focus is on enhancing healthspan by improving cellular and systemic resilience independent of the passage of time.